Title : Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides.

Pub. Date : 2012 Jun

PMID : 22344691






2 Functional Relationships(s)
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1 Here, we analyse the contributions of individual alphaCP1 KH domains to binding C-rich oligonucleotides using biophysical and structural methods. Oligonucleotides poly(rC) binding protein 1 Homo sapiens
2 Together, these data establish the lead role of KH1 in oligonucleotide binding by alphaCP1 and reveal the molecular basis of its specificity for a C-rich tetrad. Oligonucleotides poly(rC) binding protein 1 Homo sapiens