| Protein Name | poly(rC) binding protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5093 |
| Gene Symbol | PCBP1 |
| UniProt | Q15365 (PCBP1_HUMAN), Q53SS8 (Q53SS8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
49
Total Number of Articles : 63 |
Description |
poly(rC) binding protein 1 |
| Gene Summary |
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] |
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