Title : Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.

Pub. Date : 2012 Feb 21

PMID : 22308488






3 Functional Relationships(s)
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1 In addition, the Lyn-beta3 subunit significantly decreased Ca(V) channel inhibition by PIP(2) depletion. Phosphatidylinositol 4,5-Diphosphate carbonic anhydrase 5A Homo sapiens
2 Compared with expression with Ca(V) beta3-subunits alone, inhibition of Ca(V)2.2 channels by PIP(2) depletion could be significantly attenuated when beta2a was coexpressed with beta3. Phosphatidylinositol 4,5-Diphosphate carbonic anhydrase 5A Homo sapiens
3 Our data suggest that the Ca(V) currents in neurons would be regulated by membrane PIP(2) to a degree that depends on their endogenous beta-subunit combinations. Phosphatidylinositol 4,5-Diphosphate carbonic anhydrase 5A Homo sapiens