Pub. Date : 2012 Apr
PMID : 22275065
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis. | Palmitates | free fatty acid receptor 1 | Mus musculus |
| 2 | As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 3 | As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 4 | In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. | DC260126 | free fatty acid receptor 1 | Mus musculus |
| 5 | In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. | DC260126 | free fatty acid receptor 1 | Mus musculus |
| 6 | In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. | Palmitates | free fatty acid receptor 1 | Mus musculus |
| 7 | Similar results were observed in GPR40-deficient MIN6 cells, indicating that palmitate-induced beta-cell apoptosis is at least partially dependent on ER stress pathway via GRP40. | Palmitates | free fatty acid receptor 1 | Mus musculus |