PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22275065-0 2012 Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis. Palmitates 50-59 free fatty acid receptor 1 Mus musculus 14-19 22275065-2 2012 As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. Fatty Acids, Nonesterified 36-39 free fatty acid receptor 1 Mus musculus 51-56 22275065-2 2012 As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. Fatty Acids, Nonesterified 146-149 free fatty acid receptor 1 Mus musculus 51-56 22275065-3 2012 In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. DC260126 123-131 free fatty acid receptor 1 Mus musculus 55-60 22275065-3 2012 In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. DC260126 123-131 free fatty acid receptor 1 Mus musculus 171-176 22275065-3 2012 In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. Palmitates 213-222 free fatty acid receptor 1 Mus musculus 171-176 22275065-4 2012 Similar results were observed in GPR40-deficient MIN6 cells, indicating that palmitate-induced beta-cell apoptosis is at least partially dependent on ER stress pathway via GRP40. Palmitates 77-86 free fatty acid receptor 1 Mus musculus 33-38