Pub. Date : 2012 Mar 5
PMID : 22266491
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 2 | Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 3 | Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 4 | Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 5 | Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. | Nitroglycerin | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 6 | Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. | Aldehydes | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 7 | This study was performed to explore whether the cardioprotective effect of alpha lipoic acid was related to activation of ALDH2 and the underlying mechanisms. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 8 | Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 9 | Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 10 | Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 11 | Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 12 | Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. | Reactive Oxygen Species | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 13 | Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. | Reactive Oxygen Species | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 14 | Our results suggest that the cardioprotective effects of lipoic acid on ischemia-reperfusion injury are through a mechanism involving ALDH2 activation. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |
| 15 | The regulatory effect of lipoic acid on ALDH2 activity is dependent on PKCepsilon signaling pathway. | Thioctic Acid | aldehyde dehydrogenase 1 family, member A1 | Rattus norvegicus |