Title : Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.

Pub. Date : 2012 Feb

PMID : 22180294






2 Functional Relationships(s)
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Protein Name
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1 Repression of ceramide synthase 1 (CerS1), altering C(18) -ceramide generation, was linked to drug resistance and metastasis. Ceramides ceramide synthase 1 Homo sapiens
2 Thus, these data suggest that the HDAC1/miR-574-5p axis might provide a novel therapeutic target to reconstitute tumour suppressor CerS1/ceramide signalling. Ceramides ceramide synthase 1 Homo sapiens