Protein Name ceramide synthase 1
Organism Homo sapiens
Gene ID 10715
Gene Symbol

CERS1

UniProt P27544 (CERS1_HUMAN), Q5XG75 (Q5XG75_HUMAN), B4DE47 (B4DE47_HUMAN)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 86
Description

ceramide synthase 1

Gene Summary

This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]

synonyms
  • ceramide synthase 1
  • Embryonic growth/differentiation factor 1
  • longevity assurance (LAG1, S. cerevisiae) homolog 1
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Properties