Title : Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/salt-induced hypertensive rats.

Pub. Date : 2011 Dec

PMID : 22045122






1 Functional Relationships(s)
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1 RESULTS: At week 4, the DOCA-treated group exhibited hypertension, tubulointerstitial fibrosis, increased MMP2 activity in the kidney and urine, and overexpression of MMP2 in proximal tubule cells and MMP14 in apical membranes; these results were more pronounced at week 8. Desoxycorticosterone Acetate matrix metallopeptidase 14 Rattus norvegicus