Title : Characterization of an insulin receptor mutant lacking the subunit processing site.

Pub. Date : 1990 May 25

PMID : 2187866






2 Functional Relationships(s)
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1 When cells were photolabeled with 125I-B2(2-nitro-4-azidophenylacetyl)-des-PheB1 (NAPA)-insulin, the proreceptor incorporated 10% as much label as the 130-kDa alpha subunit in spite of a 5-fold molar excess. Acecainide insulin Homo sapiens
2 Immunoprecipitation of NAPA-insulin-stimulated cells with anti-phosphotyrosine antibodies revealed that 62% of the processed labeled receptors, but very little proreceptor, contained phosphotyrosine. Acecainide insulin Homo sapiens