Pub. Date : 2011 Aug
PMID : 21690296
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation. | Tyrosine | T-box 21 | Mus musculus |
| 2 | Interestingly, three tyrosine residues within the T-bet DNA-binding domain are the predominant sites of phosphorylation by c-Abl. | Tyrosine | T-box 21 | Mus musculus |
| 3 | Mutation of these tyrosine residues inhibits the promoter DNA-binding activity of T-bet. | Tyrosine | T-box 21 | Mus musculus |
| 4 | Therefore, c-Abl catalyzes tyrosine phosphorylation of the DNA-binding domain of T-bet to regulate CD4(+) T cell differentiation. | Tyrosine | T-box 21 | Mus musculus |