Pub. Date : 2011 Oct
PMID : 21688292
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain. | agomelatine | synapsin I | Rattus norvegicus |
| 2 | Chronic footshock and agomelatine induced region-specific changes in SynI expression. | agomelatine | synapsin I | Rattus norvegicus |
| 3 | Furthermore, chronic agomelatine administration decreased total SynI expression in the hippocampal subregions of both stressed and nonstressed rats. | agomelatine | synapsin I | Rattus norvegicus |
| 4 | Altogether, our data show that chronic stress and agomelatine treatment induce region-specific changes in SynI expression and its phosphorylation. | agomelatine | synapsin I | Rattus norvegicus |
| 5 | Moreover, agomelatine partially counteracts the stress effects on SynI, suggesting a modulation of synaptic function by this antidepressant. | agomelatine | synapsin I | Rattus norvegicus |