Pub. Date : 2011 Jan
PMID : 21468923
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The areas under the curve of both caffeine and its three major metabolites (paraxanthine, theophylline, and theobromine) were significantly reduced by rutaecarpine, indicating that caffeine was rapidly converted into the desmethylated metabolites, and that those were also quickly transformed into further metabolites via the hydroxyl metabolites due to the remarkable induction of CYP1A2 and 2E1. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | These results clearly suggest that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in rats. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | These results clearly suggest that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in rats. | rutecarpine | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |