Title : (R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.

Pub. Date : 2011 Mar 1

PMID : 21300547






1 Functional Relationships(s)
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1 The new sulfonamides selectively inhibited the mitochondrial isozymes hCA VA and VB (h=human isoform) over the cytosolic, off-target ones hCA I and II, with inhibition constants in the low nanomolar range. Sulfonamides carbonic anhydrase 5A Homo sapiens