Title : Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.

Pub. Date : 1990 Jun 21

PMID : 2113614






3 Functional Relationships(s)
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1 Here we report that the expression of I-Ak (A alpha kA beta k) in transgenic NOD mice can also prevent insulitis, and that this protection is seen not only when the I-A beta-chain has aspartic acid as residue 57, but also when this residue is serine. Serine histocompatibility 2, class II antigen A, beta 1 Mus musculus
2 These results show that the single amino-acid substitution at position 57 of the I-A beta-chain from aspartic acid to serine is not sufficient for the development of the disease. Aspartic Acid histocompatibility 2, class II antigen A, beta 1 Mus musculus
3 These results show that the single amino-acid substitution at position 57 of the I-A beta-chain from aspartic acid to serine is not sufficient for the development of the disease. Serine histocompatibility 2, class II antigen A, beta 1 Mus musculus