Title : Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.

Pub. Date : 2011 Mar

PMID : 21131397






6 Functional Relationships(s)
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Protein Name
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1 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Cyclic AMP adenylate cyclase 5 Mus musculus
2 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Cyclic AMP adenylate cyclase 5 Mus musculus
3 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Colforsin adenylate cyclase 5 Mus musculus
4 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Colforsin adenylate cyclase 5 Mus musculus
5 Counter to our hypothesis, isoproterenol-mediated airway relaxation was significantly attenuated (~50%) in AC5-TG, as was cAMP production, suggesting compensatory regulatory events limiting beta(2)-AR signaling when AC expression is increased. Isoproterenol adenylate cyclase 5 Mus musculus
6 Counter to our hypothesis, isoproterenol-mediated airway relaxation was significantly attenuated (~50%) in AC5-TG, as was cAMP production, suggesting compensatory regulatory events limiting beta(2)-AR signaling when AC expression is increased. Isoproterenol adenylate cyclase 5 Mus musculus