Title : The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function.

Pub. Date : 2011 Jan

PMID : 21114601






1 Functional Relationships(s)
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1 As compared with the vehicle, gene expression analysis revealed that AS1535907 significantly upregulated transcription factors (Nkx 2.2, Nkx 6.1, NeuroD and activin A), responsible for beta-cell regulation and prohormone-converting enzyme 1 responsible for insulin biosynthesis. 2-(4-bromophenyl)-6-methyl-N-(2-(1-oxidopyridin-3-yl)ethyl)pyrimidin-4-amine neurogenic differentiation 1 Mus musculus