Title : Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Pub. Date : 2010 Oct 13

PMID : 20947020






2 Functional Relationships(s)
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1 Our previous work has shown that Dvl2 links at least one Frizzled family member (Fz4) to clathrin-mediated endocytosis by interacting with the mu2 subunit of the AP-2 clathrin adaptor, through both a classical endocytic tyrosine motif and a so-called "DEP domain." Tyrosine frizzled class receptor 4 Homo sapiens
2 Mutation of residues at the DEP-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 for mu2 and block efficient internalization of Fz4 in response to ligation by Wnt5a. Tyrosine frizzled class receptor 4 Homo sapiens