Title : Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats.

Pub. Date : 2010 Aug

PMID : 20814070






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1 Interestingly, the ulcer healing and gastroprotective effects of pioglitazone were weak under diabetic conditions, and this effect on ulcer healing was accompanied by impaired angiogenesis due to decreased PECAM-1 expression, attenuated expression of COX-2 and the increased expression of proinflammatory cytokines compared to those in diabetic rats treated with vehicle. Pioglitazone platelet and endothelial cell adhesion molecule 1 Rattus norvegicus