Title : Bag1 directly routes immature BCR-ABL for proteasomal degradation.

Pub. Date : 2010 Nov 4

PMID : 20675402






1 Functional Relationships(s)
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1 Interestingly, Bag1 (Bcl-2-associated athanogene-1), a nucleotide exchange factor for Hsc70, directly bound BCR-ABL with a high affinity, which was enhanced by CHIP and Hsp90 inhibitors, inhibited by imatinib and competed with Hsc70. Imatinib Mesylate heat shock protein 8 Mus musculus