Protein Name heat shock protein 8
Organism Mus musculus
Gene ID 15481
Gene Symbol

Hspa8

UniProt P63017 (HSP7C_MOUSE)
Relationships Total Number of functionally related compound(s) : 78
Total Number of Articles : 72
Description

heat shock protein 8

Gene Summary

Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including clathrin coat disassembly; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome and regulation of cell cycle. Located in several cellular components, including extracellular exosome; late endosome; and perinuclear region of cytoplasm. Is active in several cellular components, including glycinergic synapse; photoreceptor ribbon synapse; and postsynaptic specialization membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • heat shock cognate 71 kDa protein
  • heat shock 70 kDa protein 8
  • heat shock cognate hsc73
Click to show/hide the synonyms
Properties