Pub. Date : 2010 Jul 22
PMID : 20613724
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that DAF-16 isoforms functionally cooperate to modulate IIS-mediated processes through differential tissue enrichment, preferential modulation by upstream kinases, and regulating distinct and overlapping target genes. | iis | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |
| 2 | Importantly, in mammals, four FOXO genes have overlapping and different functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-mediated processes in the context of a whole organism. | iis | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |