Pub. Date : 2011 Jan 1
PMID : 20518593
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 2 | Here we attempted to test a novel hypothesis that hypoxia may induce Ca(2+) release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PASMCs). | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 3 | Here we attempted to test a novel hypothesis that hypoxia may induce Ca(2+) release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PASMCs). | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 4 | Here we attempted to test a novel hypothesis that hypoxia may induce Ca(2+) release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PASMCs). | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 5 | Here we attempted to test a novel hypothesis that hypoxia may induce Ca(2+) release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PASMCs). | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 6 | Here we attempted to test a novel hypothesis that hypoxia may induce Ca(2+) release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PASMCs). | pasmcs | FKBP prolyl isomerase 1B | Homo sapiens |
| 7 | The colocalization of FKBP12.6 with RyRs was decreased in intact PASMCs. | pasmcs | FKBP prolyl isomerase 1B | Homo sapiens |
| 8 | Pharmacological and genetic inhibition of intracellular ROS generation prevented hypoxia from decreasing FKBP12.6 on the SR and increasing FKBP12.6 in the cytosol. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 9 | Pharmacological and genetic inhibition of intracellular ROS generation prevented hypoxia from decreasing FKBP12.6 on the SR and increasing FKBP12.6 in the cytosol. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 10 | Exogenous ROS (H(2)O(2)) reduced FKBP12.6 on the SR and augmented FKBP12.6 in the cytosol. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 11 | Exogenous ROS (H(2)O(2)) reduced FKBP12.6 on the SR and augmented FKBP12.6 in the cytosol. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 12 | Hypoxia and H(2)O(2) diminished the association of FKBP12.6 from type 2 RyRs (RyR2). | Hydrogen Peroxide | FKBP prolyl isomerase 1B | Homo sapiens |
| 13 | Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs. | Reactive Oxygen Species | FKBP prolyl isomerase 1B | Homo sapiens |
| 14 | Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs. | pasmcs | FKBP prolyl isomerase 1B | Homo sapiens |