Title : Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture.

Pub. Date : 2010 Sep 1

PMID : 20513639






3 Functional Relationships(s)
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1 Exposure of Caenorhabditis elegans worms to EGCG caused nuclear accumulation of the FoxO ortholog, DAF-16, and enhanced expression of the DAF-16 target gene, sod-3. epigallocatechin gallate Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
2 Exposure of Caenorhabditis elegans worms to EGCG caused nuclear accumulation of the FoxO ortholog, DAF-16, and enhanced expression of the DAF-16 target gene, sod-3. epigallocatechin gallate Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
3 In line with the role of FoxO/DAF-16 in the control of life span, C. elegans mean and maximum life span were enhanced by 20% and 13%, respectively, by EGCG. epigallocatechin gallate Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans