Title : The MAPK-dependent regulation of the Jagged/Notch gene expression by VEGF, bFGF or PPAR gamma mediated angiogenesis in HUVEC.

Pub. Date : 2010 Apr

PMID : 20436223






2 Functional Relationships(s)
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1 The study analyzed the signalling pathways involved in the regulation of Jagged-1/Notch-4 expression in endothelial cells (HUVECs) in response to VEGF, bFGF and PPAR-gamma exogenous activator - ciglitazone. ciglitazone jagged canonical Notch ligand 1 Homo sapiens
2 The opposite effect of VEGF, bFGF, or ciglitazone on the Jagged-1/Notch-4 expression on HUVEC was connected with the different activation of MAPKs. ciglitazone jagged canonical Notch ligand 1 Homo sapiens