Protein Name jagged canonical Notch ligand 1
Organism Homo sapiens
Gene ID 182
Gene Symbol


UniProt P78504 (JAG1_HUMAN), Q99740 (Q99740_HUMAN)
Relationships Total Number of functionally related compound(s) : 199
Total Number of Articles : 197

jagged canonical Notch ligand 1

Gene Summary

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]

  • protein jagged-1
  • AGS
  • AGS1
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