Title : Redox-regulated lipid membrane binding of the PICK1 PDZ domain.

Pub. Date : 2010 Jun 1

PMID : 20426484






3 Functional Relationships(s)
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1 In addition to binding to a wide spectrum of target proteins to be transported, the PICK1 PDZ domain, via its conserved CPC motif, has also been shown to bind to lipid membranes. cytidylyl-(3'-5')-cytidine protein interacting with PRKCA 1 Homo sapiens
2 However, the molecular basis of the CPC motif-mediated lipid membrane binding of the PICK1 PDZ domain is not known. cytidylyl-(3'-5')-cytidine protein interacting with PRKCA 1 Homo sapiens
3 Here we show that the Cys residues in the CPC motif of the PICK1 PDZ domain forms reversible, intermolecular disulfide bonds under mild oxidation conditions. cytidylyl-(3'-5')-cytidine protein interacting with PRKCA 1 Homo sapiens