Title : Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans.

Pub. Date : 2010 Jul 29

PMID : 20226839






7 Functional Relationships(s)
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1 Introduction of RNAi of fat-2, fat-6, fat-7, and elo-2 genes into the daf-16 deficient worm recovered Nile red-stained lipid storage. nile red Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
2 These results suggest that Nile red stained the lipids except TAG, and that the levels of these lipids are regulated by daf-16. nile red Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
3 Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16. Fatty Acids, Unsaturated Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
4 Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16. Fatty Acids Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
5 Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16. Linoleic Acid Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
6 Furthermore, treatment of the fat-2-RNAi worm with PUFA--using the fatty acids from linoleic acid through eicosapentaenoic acid--suppressed nuclear localization of DAF-16. Eicosapentaenoic Acid Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
7 These results suggest that PUFA acts as a mediator of daf-2/insulin signaling and that daf-16 might be involved in fatty acid homeostasis under the control of PUFA. Fatty Acids Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans