Title : HUVEC ICAM-1 and VCAM-1 synthesis in response to potentially athero-prone and athero-protective mechanical and nicotine chemical stimuli.

Pub. Date : 2010 May

PMID : 20162355






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In first and second bioreactor test cases, the addition of a pulsatile THS to the WSS resulted in opposite trends of ICAM-1 down-regulation and up-regulation, respectively. THYMIDINE-5'-(DITHIO)PHOSPHATE intercellular adhesion molecule 1 Homo sapiens
2 Similarly, in first and second bioreactor test cases, the addition of a pulsatile THS to the WSS resulted in a VCAM-1 up-regulation. THYMIDINE-5'-(DITHIO)PHOSPHATE vascular cell adhesion molecule 1 Homo sapiens
3 However, it has been previously shown that the addition of a cyclic THS to a high- or low-steady WSS resulted in a VCAM-1 down-regulation, indicating that the EC response to idealized mechanical stimuli (steady WSS and cyclic THS) is not comparable to physiological mechanical stimuli (unsteady WSS and pulsatile THS), even though in both situations the average magnitude of WSS and THS applied were similar. THYMIDINE-5'-(DITHIO)PHOSPHATE vascular cell adhesion molecule 1 Homo sapiens