Pub. Date : 2010
PMID : 20113171
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Lipid nano-emulsions (LNEs) having a mean droplet size of approximately 50 nm were investigated as drug carriers for paclitaxel (TXL) to achieve its satisfactory loadings and to develop a pharmaceutically acceptable alternative to the current formulation, Taxol. | lnes | thioredoxin like 1 | Homo sapiens | ||
| 2 | Lipid nano-emulsions (LNEs) having a mean droplet size of approximately 50 nm were investigated as drug carriers for paclitaxel (TXL) to achieve its satisfactory loadings and to develop a pharmaceutically acceptable alternative to the current formulation, Taxol. | Paclitaxel | thioredoxin like 1 | Homo sapiens | ||
| 3 | TXL was incorporated into the LNEs at 2.0 mg/ml without changes in particle size or drug precipitation. | lnes | thioredoxin like 1 | Homo sapiens | ||
| 4 | In the cytotoxicity study, TXL-loaded LNEs had cytotoxicity to HeLa cells equivalent to that of TXL alone; the 50% growth inhibitory concentrations (IC(50)) of TXL-loaded LNEs and TXL alone were 1.53 +/- 0.23 nM and 1.76 +/- 0.08 nM, respectively. | lnes | thioredoxin like 1 | Homo sapiens | ||
| 5 | In the cytotoxicity study, TXL-loaded LNEs had cytotoxicity to HeLa cells equivalent to that of TXL alone; the 50% growth inhibitory concentrations (IC(50)) of TXL-loaded LNEs and TXL alone were 1.53 +/- 0.23 nM and 1.76 +/- 0.08 nM, respectively. | lnes | thioredoxin like 1 | Homo sapiens | ||