Title : Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes.

Pub. Date : 2010 Jun

PMID : 20061215






2 Functional Relationships(s)
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1 OBJECTIVES: We evaluated the effects of exposure to PM and PM metal components on candidate miRNAs (miR-222, miR-21, and miR-146a) related with oxidative stress and inflammatory processes in 63 workers at an electric-furnace steel plant. Metals microRNA 146a Homo sapiens
2 Postexposure expression of miR-146a was not significantly different from baseline (baseline = 0.61 +/- 2.42, postexposure = 1.90 +/- 3.94, p = 0.19) but was negatively correlated with exposure to lead (beta = -0.51, p = 0.011) and cadmium (beta = -0.42, p = 0.04). Cadmium microRNA 146a Homo sapiens