PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20061215-3 2010 OBJECTIVES: We evaluated the effects of exposure to PM and PM metal components on candidate miRNAs (miR-222, miR-21, and miR-146a) related with oxidative stress and inflammatory processes in 63 workers at an electric-furnace steel plant. Metals 62-67 transmembrane protein 11 Homo sapiens 59-61 20061215-3 2010 OBJECTIVES: We evaluated the effects of exposure to PM and PM metal components on candidate miRNAs (miR-222, miR-21, and miR-146a) related with oxidative stress and inflammatory processes in 63 workers at an electric-furnace steel plant. Metals 62-67 microRNA 222 Homo sapiens 100-107 20061215-3 2010 OBJECTIVES: We evaluated the effects of exposure to PM and PM metal components on candidate miRNAs (miR-222, miR-21, and miR-146a) related with oxidative stress and inflammatory processes in 63 workers at an electric-furnace steel plant. Metals 62-67 microRNA 21 Homo sapiens 109-115 20061215-3 2010 OBJECTIVES: We evaluated the effects of exposure to PM and PM metal components on candidate miRNAs (miR-222, miR-21, and miR-146a) related with oxidative stress and inflammatory processes in 63 workers at an electric-furnace steel plant. Metals 62-67 microRNA 146a Homo sapiens 121-129 20061215-8 2010 In postexposure samples, miR-222 expression was positively correlated with lead exposure (beta = 0.41, p = 0.02), whereas miR-21 expression was associated with blood 8-hydroxyguanine (beta = 0.11, p = 0.03) but not with individual PM size fractions or metal components. 8-hydroxyguanine 166-182 microRNA 21 Homo sapiens 122-128 20061215-9 2010 Postexposure expression of miR-146a was not significantly different from baseline (baseline = 0.61 +/- 2.42, postexposure = 1.90 +/- 3.94, p = 0.19) but was negatively correlated with exposure to lead (beta = -0.51, p = 0.011) and cadmium (beta = -0.42, p = 0.04). Cadmium 231-238 microRNA 146a Homo sapiens 27-35 20061215-10 2010 CONCLUSIONS: Changes in miRNA expression may represent a novel mechanism mediating responses to PM and its metal components. Metals 107-112 transmembrane protein 11 Homo sapiens 96-98