Pub. Date : 1990 Sep
PMID : 1962841
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli. | Cyclic AMP | catabolite gene activator protein | Escherichia coli |
| 2 | As is characteristic for CytR-regulated promoters, deoP2 encodes tandem binding sites for the activating complex cAMP-CRP. | Cyclic AMP | catabolite gene activator protein | Escherichia coli |
| 3 | Furthermore, the reduction in CytR titration parallels the reduction in binding of cAMP-CRP to the mutated CRP sites in vitro. | Cyclic AMP | catabolite gene activator protein | Escherichia coli |
| 4 | Furthermore, the reduction in CytR titration parallels the reduction in binding of cAMP-CRP to the mutated CRP sites in vitro. | Cyclic AMP | catabolite gene activator protein | Escherichia coli |
| 5 | These observations are not easily explained by current models for the action of prokaryotic repressors; instead we favour a model in which the interaction of CytR with deoP2 depends on the presence of tandem DNA-bound cAMP-CRP complexes. | Cyclic AMP | catabolite gene activator protein | Escherichia coli |