PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1962841-0 1990 Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli. Cyclic AMP 17-21 catabolite gene activator protein Escherichia coli 22-25 1962841-2 1990 As is characteristic for CytR-regulated promoters, deoP2 encodes tandem binding sites for the activating complex cAMP-CRP. Cyclic AMP 113-117 catabolite gene activator protein Escherichia coli 118-121 1962841-6 1990 Furthermore, the reduction in CytR titration parallels the reduction in binding of cAMP-CRP to the mutated CRP sites in vitro. Cyclic AMP 83-87 catabolite gene activator protein Escherichia coli 88-91 1962841-6 1990 Furthermore, the reduction in CytR titration parallels the reduction in binding of cAMP-CRP to the mutated CRP sites in vitro. Cyclic AMP 83-87 catabolite gene activator protein Escherichia coli 107-110 1962841-7 1990 These observations are not easily explained by current models for the action of prokaryotic repressors; instead we favour a model in which the interaction of CytR with deoP2 depends on the presence of tandem DNA-bound cAMP-CRP complexes. Cyclic AMP 218-222 catabolite gene activator protein Escherichia coli 223-226