Pub. Date : 2010 Apr
PMID : 19597959
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. | Reactive Oxygen Species | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |
| 2 | Silencing or deletion of DAF-16 prevented the juglone-induced adaptations. | juglone | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |
| 3 | Our studies demonstrate that DAF-16- and SIR-2.1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity. | Reactive Oxygen Species | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |