Title : Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Pub. Date : 2009 Sep 25

PMID : 19589782






1 Functional Relationships(s)
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1 In support of both cell-based and animal work showing that the cytotoxic effect of ETPs is reduced by the addition of Zn(2+) through an unknown mechanism, our mechanistic studies reveal that ETPs react with p300, causing zinc ion ejection. Ethionamide E1A binding protein p300 Homo sapiens