CPRiL

EP300

E1A binding protein p300

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

• histone acetyltransferase p300
• E1A-associated protein p300
• E1A-binding protein, 300kD
histone butyryltransferase p300
histone crotonyltransferase p300
p300 HAT
protein 2-hydroxyisobutyryltransferase p300
protein lactyltransferas p300
protein propionyltransferase p300
KAT3B
MKHK2
RSTS2
p300