Protein Name E1A binding protein p300
Organism Homo sapiens
Gene ID 2033
Gene Symbol


UniProt Q09472 (EP300_HUMAN), Q7Z6C1 (Q7Z6C1_HUMAN)
Relationships Total Number of functionally related compound(s) : 638
Total Number of Articles : 1177

E1A binding protein p300

Gene Summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

  • histone acetyltransferase p300
  • E1A-associated protein p300
  • E1A-binding protein, 300kD
Click to show/hide the synonyms