Title : Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.

Pub. Date : 2009 Jul

PMID : 19571397






4 Functional Relationships(s)
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1 (99m)Tc-anti-MT1-MMP mAb was prepared using HYNIC as a bifunctional chelating agent and immunoreactivity was evaluated by flow cytometry. Technetium matrix metallopeptidase 14 Rattus norvegicus
2 (99m)Tc-anti-MT1-MMP mAb was obtained with 84% immunoreactivity to MT1-MMP and more than 92% radiochemical purity. Technetium matrix metallopeptidase 14 Rattus norvegicus
3 (99m)Tc-anti-MT1-MMP mAb was obtained with 84% immunoreactivity to MT1-MMP and more than 92% radiochemical purity. Technetium matrix metallopeptidase 14 Rattus norvegicus
4 The results suggest that (99m)Tc-anti-MT1-MMP mAb is a promising probe for future diagnosis of breast tumors by in vivo nuclear medical imaging. Technetium matrix metallopeptidase 14 Rattus norvegicus