Title : Requirement of central ghrelin signaling for alcohol reward.

Pub. Date : 2009 Jul 7

PMID : 19564604






5 Functional Relationships(s)
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1 By contrast, central or peripheral administration of ghrelin receptor (GHS-R1A) antagonists suppressed alcohol intake in this model. Alcohols growth hormone secretagogue receptor Mus musculus
2 By contrast, central or peripheral administration of ghrelin receptor (GHS-R1A) antagonists suppressed alcohol intake in this model. Alcohols growth hormone secretagogue receptor Mus musculus
3 Alcohol-induced locomotor stimulation, accumbal dopamine release and conditioned place preference were abolished in models of suppressed central ghrelin signaling: GHS-R1A knockout mice and mice treated with 2 different GHS-R1A antagonists. Alcohols growth hormone secretagogue receptor Mus musculus
4 Alcohol-induced locomotor stimulation, accumbal dopamine release and conditioned place preference were abolished in models of suppressed central ghrelin signaling: GHS-R1A knockout mice and mice treated with 2 different GHS-R1A antagonists. Alcohols growth hormone secretagogue receptor Mus musculus
5 Thus, central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol. Alcohols growth hormone secretagogue receptor Mus musculus