Title : Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.

Pub. Date : 2009 Jul 1

PMID : 19535644






3 Functional Relationships(s)
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1 Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells. Tryptophan leukocyte immunoglobulin like receptor B4 Homo sapiens
2 Functionally, tryptophan-deprived DCs show a reduced capacity to stimulate T cells, which can be restored by blockade of ILT3. Tryptophan leukocyte immunoglobulin like receptor B4 Homo sapiens
3 The generation of ILT3(high)ILT4(high) DCs with tolerogenic properties by tryptophan deprivation is linked to a stress response pathway mediated by the GCN2 kinase. Tryptophan leukocyte immunoglobulin like receptor B4 Homo sapiens