Title : [Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells].

Pub. Date : 2009 Jun

PMID : 19500499






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1 [Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells]. Losartan cellular communication network factor 2 Mus musculus
2 [Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells]. Glucose cellular communication network factor 2 Mus musculus
3 AIM: To investigate the effects and mechanism of losartan on expression of CTGF induced by high glucose. Losartan cellular communication network factor 2 Mus musculus
4 AIM: To investigate the effects and mechanism of losartan on expression of CTGF induced by high glucose. Glucose cellular communication network factor 2 Mus musculus
5 The protein expression of phosphor-ERK1/2 and CTGF were increased in high glucose group comparing with low glucose group(P<0.01), and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.05). Glucose cellular communication network factor 2 Mus musculus
6 The protein expression of phosphor-ERK1/2 and CTGF were increased in high glucose group comparing with low glucose group(P<0.01), and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.05). Glucose cellular communication network factor 2 Mus musculus
7 The protein expression of phosphor-ERK1/2 and CTGF were increased in high glucose group comparing with low glucose group(P<0.01), and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.05). Losartan cellular communication network factor 2 Mus musculus
8 The protein expression of phosphor-ERK1/2 and CTGF were increased in high glucose group comparing with low glucose group(P<0.01), and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.05). Glucose cellular communication network factor 2 Mus musculus
9 The mRNA expression of CTGF was increased in high glucose group comparing with low glucose group(P<0.01) , and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.01). Glucose cellular communication network factor 2 Mus musculus
10 The mRNA expression of CTGF was increased in high glucose group comparing with low glucose group(P<0.01) , and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.01). Glucose cellular communication network factor 2 Mus musculus
11 The mRNA expression of CTGF was increased in high glucose group comparing with low glucose group(P<0.01) , and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.01). Losartan cellular communication network factor 2 Mus musculus
12 The mRNA expression of CTGF was increased in high glucose group comparing with low glucose group(P<0.01) , and reduced in losartan group and ERK inhibitors group comparing with high glucose group(P<0.01). Glucose cellular communication network factor 2 Mus musculus
13 CONCLUSION: Losartan can inhibit high glucose-induced CTGF expression in mouse mesangial cells, and the mechanisms maybe involve the interruption of ERK1/2 MAPK pathway. Losartan cellular communication network factor 2 Mus musculus
14 CONCLUSION: Losartan can inhibit high glucose-induced CTGF expression in mouse mesangial cells, and the mechanisms maybe involve the interruption of ERK1/2 MAPK pathway. Glucose cellular communication network factor 2 Mus musculus