Title : Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence.

Pub. Date : 2009 Jul

PMID : 19493573






1 Functional Relationships(s)
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1 We show here that pre-treatment of trophoblast cells and certain cancer cells with agents that activate stress pathways (Ras oncogene, PMA or H2O2) and induce senescence can substantially enhance the induction of immune response genes (MHC class II, CD40, MICA, MICB) by HDACi and restore a vigorous IFN-gamma response in trophoblast cells and tumor cells. Hydrogen Peroxide MHC class I polypeptide-related sequence B Homo sapiens