Title : Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells.

Pub. Date : 2009 Nov

PMID : 19443729






3 Functional Relationships(s)
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1 The hypothesis was that a differential effect on MMPs and TIMPs in ciliary body smooth muscle (CBSM) cells would relate to the relative intraocular pressure-lowering effectiveness of the prostaglandin analogues (PGAs) bimatoprost, latanoprost, and unoprostone. Bimatoprost matrix metallopeptidase 1 Homo sapiens
2 Bimatoprost and latanoprost increased MMP-9 activity by 75% +/- 27% and 75% +/- 24%, respectively. Bimatoprost matrix metallopeptidase 9 Homo sapiens
3 TIMP-2 was unchanged by bimatoprost and latanoprost, but decreased by unoprostone (35% +/- 8%). Bimatoprost TIMP metallopeptidase inhibitor 2 Homo sapiens