Pub. Date : 2009 Apr
PMID : 19371592
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protein L-isoaspartyl methyltransferase (PIMT) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins. | l | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 2 | The protein L-isoaspartyl methyltransferase (PIMT) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins. | isoaspartyl | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 3 | Recently, we reported that PIMT expression was stimulated by the anti-epileptic drug valproic acid and that this was mediated through the glycogen synthase kinase-3 (GSK-3)/beta-catenin pathway. | Valproic Acid | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 4 | In this study, to gain further insights into which of the signaling pathways activated by valproic acid regulate PIMT abundance, astrocytoma U-87 MG and neuroblastoma SH-SY5Y cells were treated with this drug to investigate the possible involvement of the extracellular-regulated kinase (ERK) pathway in PIMT induction. | Valproic Acid | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 5 | Pharmacological inhibitors against the kinases Src, c-Raf, MEK1/2 and ERK1/2 abolished the ERK1/2 phosphorylation stimulated by valproic acid, thus preventing PIMT induction by the drug. | Valproic Acid | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 6 | Furthermore, MEK1/2 inhibition with U0126 blocked the higher phosphorylation of RSK-1 on Thr359/Ser363 and of GSK-3beta on Ser9 as well as the increased expression of RSK-1, beta-catenin and PIMT upon treatment with valproic acid. | U 0126 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |
| 7 | Thus, our findings demonstrated that PIMT up-regulation by valproic acid required the activation of the ERK signaling pathway including RSK-1 the latter being responsible for inactivating GSK-3 and subsequently leading to beta-catenin stabilization. | Valproic Acid | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Homo sapiens |