Title : Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2.

Pub. Date : 2009 May 21

PMID : 19363523






2 Functional Relationships(s)
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1 Strikingly, hepta-phosphorylation of all Ser and Thr residues increased binding 40- and 80-fold with CH3 and Taz1, respectively, but not with Kix or IBiD. Heptachlor zinc finger and BTB domain containing 18 Homo sapiens
2 Binding of Mdm2 to TAD was reduced significantly only on phosphorylation of Thr18 (sevenfold) or by hepta-phosphorylation (24-fold). Heptachlor MDM2 proto-oncogene Homo sapiens