Pub. Date : 2009 Apr
PMID : 19237549
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of Blimp-1 and AP-1 dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of the IgM response by B cells. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |
| 2 | In lipopolysaccharide (LPS)-activated murine B cell lymphoma, CH12.LX, Blimp-1 messenger RNA, and DNA-binding activity within the Pax5 promoter were suppressed by TCDD. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |
| 3 | TCDD treatment of LPS-activated CH12.LX cells suppressed AP-1 binding to these motifs between 24 and 72 h, in concordance with the suppression of Blimp-1 by TCDD. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |
| 4 | TCDD treatment of LPS-activated CH12.LX cells suppressed AP-1 binding to these motifs between 24 and 72 h, in concordance with the suppression of Blimp-1 by TCDD. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |
| 5 | A more comprehensive analysis at 72 h demonstrated that the suppression of AP-1 binding within the Blimp-1 promoter by TCDD was concentration dependent. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |
| 6 | In summary, our findings link the TCDD-mediated suppression of Blimp-1 through AP-1 to the dysregulation of Pax5, which ultimately leads to the suppression of B cell differentiation and humoral immune responses. | Polychlorinated Dibenzodioxins | PR domain containing 1, with ZNF domain | Mus musculus |