Title : Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.

Pub. Date : 2009 May 18

PMID : 19147279






2 Functional Relationships(s)
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1 We found that rapamycin treatment of Lkb1(+/-) mice initiated before the onset of polyposis in Lkb1(+/-) mice led to a dramatic reduction in both polyp burden and polyp size and this reduction was associated with decreased phosphorylation levels of S6 and 4EBP1. Sirolimus serine/threonine kinase 11 Mus musculus
2 We found that rapamycin treatment of Lkb1(+/-) mice initiated before the onset of polyposis in Lkb1(+/-) mice led to a dramatic reduction in both polyp burden and polyp size and this reduction was associated with decreased phosphorylation levels of S6 and 4EBP1. Sirolimus serine/threonine kinase 11 Mus musculus