Title : Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway.

Pub. Date : 2009 Mar

PMID : 19109527






1 Functional Relationships(s)
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1 We observed that simvastatin stimulation of rat BMSCs resulted in significantly increased expression of endothelial-specific genes and proteins, including von Willebrand factor (vWF), CD31, vascular endothelial-cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGFR2, Flk-1), and VEGF receptor 1 (VEGFR-1, Flt-1). Simvastatin platelet and endothelial cell adhesion molecule 1 Rattus norvegicus