Pub. Date : 2009 Jul
PMID : 19076981
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcitonin gene-related peptide mediates the cardioprotective effects of rutaecarpine against ischaemia-reperfusion injury in spontaneously hypertensive rats. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | It has been shown that calcitonin gene-related peptide (CGRP) plays an important role in mediating the cardioprotection exerted by rutaecarpine in normal animals. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | It has been shown that calcitonin gene-related peptide (CGRP) plays an important role in mediating the cardioprotection exerted by rutaecarpine in normal animals. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | The aim of the present study was to determine whether rutaecarpine is able to decrease the susceptibility of hypertensive animals to ischaemia-reperfusion injury by stimulating CGRP release. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | The effect of 10 or 30 micromol/L rutaecarpine on CGRP release was also examined in isolated aortic rings set up in a homeothermal organ bath. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 6 | Rutaecarpine treatment resulted in a hypotensive effect in SHR concomitant with increases in plasma CGRP levels. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 7 | In addition, rutaecarpine significantly stimulated the release of CGRP from aortic rings. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 8 | The results of the present study suggest that the increased cardiac susceptibility to ischaemia-reperfusion injury in SHR is related to decreased plasma CGRP levels and that antihypertensive therapy with rutaecarpine reverses cardiac susceptibility to reperfusion injury by stimulating CGRP release. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 9 | The results of the present study suggest that the increased cardiac susceptibility to ischaemia-reperfusion injury in SHR is related to decreased plasma CGRP levels and that antihypertensive therapy with rutaecarpine reverses cardiac susceptibility to reperfusion injury by stimulating CGRP release. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |