Title : Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.

Pub. Date : 2008 Nov 27

PMID : 19038035






4 Functional Relationships(s)
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1 BACKGROUND: This study was performed to characterize a gene-addition transgenic mouse containing a BAC (bacterial artificial chromosome) clone spanning the human CYP2C18&19 genes (tg-CYP2C18&19). Adenosine Monophosphate cytochrome P450 family 2 subfamily C member 18 Homo sapiens
2 In female tg-CYP2C18&19, the tissue weights were lower for brain (p < or = 0.001) and spleen (p < or = 0.001) compared to wild-type females. Adenosine Monophosphate cytochrome P450 family 2 subfamily C member 18 Homo sapiens
3 Male tg-CYP2C18&19 had increased blood glucose levels (p < or = 0.01) while females had decreased blood triglyceride levels (p < or = 0.01). Adenosine Monophosphate cytochrome P450 family 2 subfamily C member 18 Homo sapiens
4 Male tg-CYP2C18&19 had increased blood glucose levels (p < or = 0.01) while females had decreased blood triglyceride levels (p < or = 0.01). Glucose cytochrome P450 family 2 subfamily C member 18 Homo sapiens